Arrieta-Cortes R. auteur aut IRD Farias P. auteur aut IRD Hoyo-Vadillo C. auteur aut IRD Kleiche Dray Mina auteur aut IRD text journalArticle eng text/pdf born digital access Perfluoroalkyls are stable synthetic chemicals, able to repel oils, fats and water. These compounds have been used in the manufacturing of products such as Teflon, lubricants, paints, fire-fighting foams, coatings for pans, carpets, clothes, and paperboard for packaging, among others. It is believed that populations are exposed constantly to them. Its regulation in the world is under development and several controversies are in the course of litigation. One occupational study shows bladder cancer risk. This paper intends to review scientific information on the most critical perfluoroalkyl compound and proposes a procedure to get a cancer-risk categorization which PFOS can cause to populations. Methods: As a guiding axis, we used the IARC process for developing monographs of carcinogenic risks. We used the SIGN guides for evaluating the quality of studies in human populations; and finally, we used the Squire method for evaluating studies in laboratory animals. Inadequate evidence of carcinogenicity was found in human studies mainly due to chance, threshold effect and confounders. In experimental animal studies, inadequate evidence of carcinogenicity was found in view of the number of affected species, different types of neoplasms, dose-response relationship and genotoxicity found in in-vivo and in-vitro studies. In this proposal, we concluded that cancer risk for PFOS, according to the IARC method, is not classifiable as carcinogenic to humans (group 3). specialized PFCs PFOS Perfluorooctane sulfonate Carcinogenic risk IARC Genotoxicity Risk assessment Cancer MEXIQUE 050 020 116 83 66-80 2017 0273-2300 https://www.documentation.ird.fr/hor/fdi:010068919 10.1016/j.yrtph.2016.11.021 0273-2300 [F B010068919] https://www.documentation.ird.fr/hor/fdi:010068919 https://www.documentation.ird.fr/intranet/publi/2017/02/010068919.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2017-03-02 2023-07-11 fdi:010068919 fre