Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Tetrahedron Letters 4922-4925 [+ 12 ] 2016 fdi:010068406 ENG Tetrahedron Letters 0040-4039 ISI:000386415300011 44 10.1016/j.tetlet.2016.09.075 https://www.documentation.ird.fr/hor/fdi:010068406 https://www.documentation.ird.fr/intranet/publi/depot/2016-10-19/010068406.pdf 57 Horizon (IRD) Highly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. Its biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. Mucor circinelloides ATCC 8541 was able to structurally modify ilimaquinone into three different compounds. A stereospecific epoxidation was observed and compared to chemical epoxidation. A hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. Compounds were evaluated against several cell lines. 035 ; 034 UR241 / UR195