<?xml version="1.0"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Biotransformations versus chemical modifications : new cytotoxic analogs of marine sesquiterpene ilimaquinone [plus Supporting information]</dc:title>
  <dc:creator>Boufridi, A.</dc:creator>
  <dc:creator>/Petek, Sylvain</dc:creator>
  <dc:creator>Evanno, L.</dc:creator>
  <dc:creator>Beniddir, M.A.</dc:creator>
  <dc:creator>/Debitus, C&#xE9;cile</dc:creator>
  <dc:creator>Buisson, D.</dc:creator>
  <dc:creator>Poupon, E.</dc:creator>
  <dc:description>Highly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. Its biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. Mucor circinelloides ATCC 8541 was able to structurally modify ilimaquinone into three different compounds. A stereospecific epoxidation was observed and compared to chemical epoxidation. A hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. Compounds were evaluated against several cell lines.</dc:description>
  <dc:date>2016</dc:date>
  <dc:type>text</dc:type>
  <dc:identifier>https://www.documentation.ird.fr/hor/fdi:010068406</dc:identifier>
  <dc:identifier>fdi:010068406</dc:identifier>
  <dc:identifier>Boufridi A., Petek Sylvain, Evanno L., Beniddir M.A., Debitus C&#xE9;cile, Buisson D., Poupon E.. Biotransformations versus chemical modifications : new cytotoxic analogs of marine sesquiterpene ilimaquinone [plus Supporting information]. 2016, 57 (44), 4922-4925 [+ 12 ]</dc:identifier>
  <dc:language>EN</dc:language>
</oai_dc:dc>