Publications des scientifiques de l'IRD

Wammes L. J., Hamid F., Wiria A. E., May L., Kaisar M. M. M., Prasetyani-Gieseler M. A., Djuardi Y., Wibowo H., Kruize Y. C. M., Verweij J. J., de Jong S. E., Tsonaka R., Houwing-Duistermaat J. J., Sartono E., Luty Adrian, Supali T., Yazdanbakhsh M. (2016). Community deworming alleviates geohelminth-induced immune hyporesponsiveness. Proceedings of the National Academy of Sciences of the United States of America, 113 (44), p. 12526-12531. ISSN 0027-8424.

Titre du document
Community deworming alleviates geohelminth-induced immune hyporesponsiveness
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000386608200061
Auteurs
Wammes L. J., Hamid F., Wiria A. E., May L., Kaisar M. M. M., Prasetyani-Gieseler M. A., Djuardi Y., Wibowo H., Kruize Y. C. M., Verweij J. J., de Jong S. E., Tsonaka R., Houwing-Duistermaat J. J., Sartono E., Luty Adrian, Supali T., Yazdanbakhsh M.
Source
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (44), p. 12526-12531 ISSN 0027-8424
In cross-sectional studies, chronic helminth infections have been associated with immunological hyporesponsiveness that can affect responses to unrelated antigens. To study the immunological effects of deworming, we conducted a cluster-randomized, double-blind, placebo-controlled trial in Indonesia and assigned 954 households to receive albendazole or placebo once every 3 mo for 2 y. Helminth-specific and nonspecific whole-blood cytokine responses were assessed in 1,059 subjects of all ages, whereas phenotyping of regulatory molecules was undertaken in 121 school-aged children. All measurements were performed before and at 9 and 21 mo after initiation of treatment. Anthelmintic treatment resulted in significant increases in proinflammatory cytokine responses to Plasmodium falciparum-infected red blood cells (PfRBCs) and mitogen, with the largest effect on TNF responses to PfRBCs at 9 mo-estimate [95% confidence interval], 0.37 [0.21-0.53], P value over time (P-time) < 0.0001. Although the frequency of regulatory T cells did not change after treatment, there was a significant decline in the expression of the inhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) on CD4(+) T cells of albendazole-treated individuals, -0.060 [-0.107 to -0.013] and -0.057 [-0.105 to -0.008] at 9 and 21 mo, respectively; P-time = 0.017. This trial shows the capacity of helminths to up-regulate inhibitory molecules and to suppress proinflammatory immune responses in humans. This could help to explain the inferior immunological responses to vaccines and lower prevalence of inflammatory diseases in low- compared with high-income countries.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
INDONESIE ; FLORES ILE
Localisation
Fonds IRD [F B010068316]
Identifiant IRD
fdi:010068316
Contact