%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Chassagne, F.
%A Rojas, T. R.
%A Bertani, Stéphane
%A Bourdy, Geneviève
%A Eav, S.
%A Ruiz, E.
%A Pineau, P.
%A Deharo, Eric
%T A 13-year retrospective study on primary liver cancer in Cambodia : a strikingly high hepatitis C occurrence among hepatocellular carcinoma cases
%D 2016
%L fdi:010067735
%G ENG
%J Oncology
%@ 0030-2414
%K Hepatocellular carcinoma ; Cholangiocarcinoma ; Hepatitis B virus ; Hepatitis C virus ; Opisthorchis viverrini ; Cambodia
%K CAMBODGE
%M ISI:000381655900007
%N 2
%P 106-116
%R 10.1159/000446398
%U https://www.documentation.ird.fr/hor/fdi:010067735
%> https://www.documentation.ird.fr/intranet/publi/2016/09/010067735.pdf
%V 91
%W Horizon (IRD)
%X Objectives: Hepatocellular carcinoma (HCC) is the main type of primary liver cancer (PLC) worldwide, but cholangio-carcinoma (CCA) may be predominant in some specific regions of Southeast Asia. The aim of the present study was to delineate a pattern of Cambodian PLC patients attending the Calmette Hospital in the Cambodian capital Phnom Penh. Materials and Methods: A total of 553 medical charts diagnosing PLCs from January 2003 to May 2015 were obtained from both the Oncology and Hepato-Gastroenterology Departments of the Calmette Hospital. Results: HCC was the predominant type of PLC recorded, with 511 cases (92.4%), whereas CCA represented merely 7.6% (42 cases) of the overall series. Hepatitis B virus (HBV; 44.3%) and hepatitis C virus (HCV; 43%) infection rates were similar among the HCC patients, while small subsets of CCA patients were infected with HBV (15.4%) or HCV (11.5%). Most HCC (84%) and CCA (73.8%) patients received palliative treatment only. Conclusion: The present study indicates that HCC is the main form of primary hepatic neoplasm among PLC patients attending a hospital in Cambodia. HBV and HCV infections represented equivalent burdens and major contributing factors to HCC. Therefore, the implementation of prevention programs for these infectious agents should become a priority for health policy makers in the country.
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