@article{fdi:010066993,
  title = {{T}rypanosome-induced {I}nterferon-gamma production in whole blood stimulation assays is associated with latent {T}rypanosoma brucei gambiense infections},
  author = {{I}lboudo, {H}. and {J}amonneau, {V}incent and {K}offi, {M}. and {K}abore, {J}. and {A}moussa, {R}. and {H}olzmuller, {P}. and {G}arcia, {A}ndr{\'e} and {B}ucheton, {B}runo and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontrol of human {A}frican trypanosomiasis ({HAT}) is highly dependent on the ability to detect and treat infected individuals. {H}owever, a number of individuals exposed to {T}rypanosoma brucei gambiense are able to control infection to undetectable levels in blood. {T}hey are long-term potential reservoirs and thus a threat for control strategies. {C}ytokine responses in whole blood stimulation assays were quantified in individuals with contrasting {HAT} status. {T}rypanosome-induced {IFN}-gamma production was only observed in "trypanotolerant" subjects suspected of harboring latent infections. {T}his result contributes new insights into the immune responses associated with infection control and opens novel diagnosis perspectives regarding {HAT} elimination.},
  keywords = {{H}uman {A}frican trypanosomiasis ; {T}rypanotolerance ; {C}ytokines ; {IFN}-gamma ; {W}hole blood stimulation ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{M}icrobes and {I}nfection},
  volume = {18},
  numero = {6},
  pages = {436--440},
  ISSN = {1286-4579},
  year = {2016},
  DOI = {10.1016/j.micinf.2016.03.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066993},
}