@article{fdi:010066981,
  title = {{P}lasmodium falciparum infection and age influence parasite growth inhibition mediated by {I}g{G} in {B}eninese infants},
  author = {{A}damou, {R}. and {C}henou, {F}. and {S}adissou, {I}. and {S}onon, {P}. and {D}echavanne, {C}. and {D}jilali-{S}aiah, {A}. and {C}ottrell, {G}illes and {L}e {P}ort, {A}. and {M}assougbodji, {A}. and {R}emarque, {E}. {J}. and {L}uty, {A}drian and {S}anni, {A}. and {G}arcia, {A}ndr{\'e} and {M}igot {N}abias, {F}lorence and {M}ilet, {J}acqueline and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ntibodies that impede the invasion of {P}lasmodium falciparum ({P}. falciparum) merozoites into erythrocytes play a critical role in anti-malarial immunity. {T}he {G}rowth {I}nhibition {A}ssay ({GIA}) is an in vitro measure of the functional capacity of such antibodies to limit erythrocyte invasion and/or parasite growth. {U}p to now, it is unclear whether growth-inhibitory activity correlates with protection from clinical disease and there are inconsistent results from studies performed with {GIA}. {S}tudies that have focused on the relationship between {I}g{G}s and their in vitro parasite {G}rowth {I}nhibition {A}ctivity ({GIA}c) in infants aged less than two years old are rare. {H}ere, we used clinical and parasitological data to precisely define symptomatic or asymptomatic infection with {P}. falciparum in groups of infants followed-up actively for 18 months post-natally. {W}e quantified the levels of {I}g{G}1 and {I}g{G}3 directed to a panel of candidate {P}. falciparum vaccine antigens ({AMA}-1, {MSP}1, 2, 3 and {GLURP}) using {ELISA} and the functional activity of {I}g{G} was quantified using {GIA}. {D}ata were then correlated with individuals' infection status. {A}t 18 months of age, infants harbouring infections at the time of blood sampling had an average 19% less {GIA}c than those not infected (p = 0.004, multivariate linear regression). {GIA}c decreased from 12 to 18 months of age (p = 0.003, {W}ilcoxon matched pairs test). {A}ntibody levels quantified at 18 months in infants were strongly correlated with their exposure to malarial infection, however {GIA}c was not correlated with malaria infectious status (asymptomatic and symptomatic groups). {I}n conclusion, both infection status at blood draw and age influence parasite growth inhibition mediated by {I}g{G} in the {GIA}. {B}oth factors must be taken into account when correlations between {GIA}c and anti-malarial protection or vaccine efficacy have to be made.},
  keywords = {{P}lasmodium falciparum ; {M}alaria ; {A}ntibodies ; {I}g{G} ; {GIA} ; {C}andidate vaccine antigens ; {BENIN}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {159},
  numero = {},
  pages = {111--119},
  ISSN = {0001-706{X}},
  year = {2016},
  DOI = {10.1016/j.actatropica.2016.03.020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066981},
}