@article{fdi:010066896,
  title = {{N}eemazal ({R}) as a possible alternative control tool for malaria and {A}frican trypanosomiasis ?},
  author = {{Y}erbanga, {R}. {S}. and {R}ayaisse, {J}. {B}. and {V}antaux, {A}m{\'e}lie and {S}alou, {E}. and {M}ouline, {K}arine and {H}ien, {F}. and {H}abluetzel, {A}. and {D}abir{\'e}, {R}. {K}. and {O}u{\'e}draogo, {J}. {B}. and {S}olano, {P}hilippe and {L}ef{\`e}vre, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {R}esearch efforts to identify possible alternative control tools for malaria and {A}frican trypanosomiasis are needed. {O}ne promising approach relies on the use of traditional plant remedies with insecticidal activities. {M}ethods: {I}n this study, we assessed the effect of blood treated with different doses of {N}eem{A}zal ({R}) ({NA}, neem seed extract) on mosquitoes ({A}nopheles coluzzii) and tsetse flies ({G}lossina palpalis gambiensis) (i) avidity to feed on the treated blood, (ii) longevity, and (iii) behavioural responses to human and calf odours in dual-choice tests. {W}e also gauged {N}eem{A}zal ({R}) toxicity in mice. {R}esults: {I}n {A}n. coluzzii, the ingestion of {NA} in bloodmeals offered by membrane feeding resulted in (i) primary antifeedancy; (ii) decreased longevity; and (iii) reduced response to host odours. {I}n {G}. palpalis gambiensis, {NA} caused (i) a knock-down effect; (ii) decreased or increased longevity depending on the dose; and (iii) reduced response to host stimuli. {I}n both cases, {NA} did not affect the anthropophilic rate of activated insects. {O}verall, the most significant effects were observed with {NA} treated bloodmeals at a dose of 2000 mu g/ml for mosquitoes and 50 mu g/ml for tsetse flies. {A}lthough no mortality in mice was observed after 14 days of follow-up at oral doses of 3.8, 5.6, 8.4 and 12.7 g/kg, behavioural alterations were noticed at doses above 8 g/kg. {C}onclusion: {T}his study revealed promising activity of {NA} on {A}. coluzzii and {G}. palpalis gambiensis but additional research is needed to assess field efficacy of neem products to be possibly integrated in vector control programmes.},
  keywords = {{A}nopheles coluzzii ; {G}lossina palpalis gambiensis ; {A}frican trypanosomes ; {M}alaria parasite ; {N}eem ; {N}eem{A}zal ({R}) ; {H}ost-seeking behaviours ; {A}nthropophily ; {V}ector-borne diseases ; {BURKINA} {FASO} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {9},
  numero = {},
  pages = {art. 263 [14 p.]},
  ISSN = {1756-3305},
  year = {2016},
  DOI = {10.1186/s13071-016-1538-x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066896},
}