Gantt S. auteur aut IRD Leister E. auteur aut IRD Jacobsen D. L. auteur aut IRD Boucoiran I. auteur aut IRD Huang M. L. auteur aut IRD Jerome K. R. auteur aut IRD Jourdain Gonzague auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Burchett S. auteur aut IRD Frenkel L. auteur aut IRD text journalArticle eng text/pdf born digital access Background: Congenital cytomegalovirus (cCMV) infection is common among infants born to HIV-infected women. Nelfinavir (NFV), an antiretroviral drug that is safe during pregnancy, inhibits CMV replication in vitro at concentrations that standard doses achieve in plasma. We hypothesized that infants born to women receiving NFV for prevention of mother-to-child transmission of HIV (PMTCT) would have a reduced prevalence of cCMV infection. Methods: The prevalence of cCMV infection was compared among HIV-uninfected infants whose HIV-infected mothers either received NFV for 4 weeks during pregnancy (NFV-exposed) or did not receive any NFV in pregnancy (NFV-unexposed). CMV PCR was performed on infant blood samples collected at <3 weeks from birth. Results: Of the 1,255 women included, 314 received NFV for 4 weeks during pregnancy and 941 did not receive any NFV during pregnancy. The overall prevalence of cCMV infection in the infants was 2.2%, which did not differ by maternal NFV use. Maternal CD4 T cell counts were inversely correlated with risk of cCMV infection, independent of the time NFV was initiated during gestation. Infants with cCMV infection were born 0.7 weeks earlier (P=0.010) and weighed 170g less (P=0.009) than uninfected infants. Conclusion: Among HIV-exposed uninfected infants, cCMV infection was associated with adverse perinatal outcomes. NFV use in pregnancy was not associated with protection against cCMV. Safe and effective strategies to prevent cCMV infection are needed. J. Med. Virol. 88:1051-1058, 2016. specialized congenital cytomegalovirus infection nelfinavir HIV-exposed uninfected infants ETATS UNIS EUROPE BRESIL BAHAMAS 052 050 88 6 1051-1058 2016 0146-6615 https://www.documentation.ird.fr/hor/fdi:010066767 10.1002/jmv.24420 0146-6615 [F B010066767] https://www.documentation.ird.fr/hor/fdi:010066767 https://www.documentation.ird.fr/intranet/publi/2016/05/010066767.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2016-06-02 2017-08-23 fdi:010066767 fre