@article{fdi:010066705,
  title = {{G}enomes of cryptic chimpanzee {P}lasmodium species reveal key evolutionary events leading to human malaria},
  author = {{S}undararaman, {S}. {A}. and {P}lenderleith, {L}. {J}. and {L}iu, {W}. {M}. and {L}oy, {D}. {E}. and {L}earn, {G}. {H}. and {L}i, {Y}. {Y}. and {S}haw, {K}. {S}. and {A}youba, {A}hidjo and {P}eeters, {M}artine and {S}peede, {S}. and {S}haw, {G}. {M}. and {B}ushman, {F}. {D}. and {B}risson, {D}. and {R}ayner, {J}. {C}. and {S}harp, {P}. {M}. and {H}ahn, {B}. {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}frican apes harbour at least six {P}lasmodium species of the subgenus {L}averania, one of which gave rise to human {P}lasmodium falciparum. {H}ere we use a selective amplification strategy to sequence the genome of chimpanzee parasites classified as {P}lasmodium reichenowi and {P}lasmodium gaboni based on the subgenomic fragments. {G}enome-wide analyses show that these parasites indeed represent distinct species, with no evidence of cross-species mating. {B}oth {P}. reichenowi and {P}. gaboni are 10-fold more diverse than {P}. falciparum, indicating a very recent origin of the human parasite. {W}e also find a remarkable {L}averania-specific expansion of a multigene family involved in erythrocyte remodelling, and show that a short region on chromosome 4, which encodes two essential invasion genes, was horizontally transferred into a recent {P}. falciparum ancestor. {O}ur results validate the selective amplification strategy for characterizing cryptic pathogen species, and reveal evolutionary events that likely predisposed the precursor of {P}. falciparum to colonize humans.},
  keywords = {{CAMEROUN} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {7},
  numero = {},
  pages = {art. 11078 [14 p.]},
  ISSN = {2041-1723},
  year = {2016},
  DOI = {10.1038/ncomms11078},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066705},
}