%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A d'Almeida, T. C.
%A Sadissou, I.
%A Cottrell, Gilles
%A Tahar, Rachida
%A Moreau, P.
%A Favier, B.
%A Moutairou, K.
%A Donadi, E. A.
%A Massougbodji, A.
%A Rouass-Freiss, N.
%A Courtin, David
%A Garcia, André
%T Evolution of the levels of human leukocyte antigen G (HLA-G) in Beninese infant during the first year of life in a malaria endemic area : using latent class analysis
%D 2016
%L fdi:010066187
%G ENG
%J Malaria Journal
%@ 1475-2875
%K sHLA-G ; Evolution ; Groups ; Infancy ; Malaria ; Benin
%K BENIN
%M ISI:000369569100005
%P art. 78 [10 ]
%R 10.1186/s12936-016-1131-y
%U https://www.documentation.ird.fr/hor/fdi:010066187
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers16-03/010066187.pdf
%V 15
%W Horizon (IRD)
%X Background: HLA-G, a non-classical HLA class I antigen, is of crucial interest during pregnancy by inhibiting maternal immune response. Its role during infections is discussed, and it has been described that high levels of soluble HLA-G during childhood increase the risk of malaria. To explore more precisely interactions between soluble HLA-G and malaria, latent class analysis was used to test whether distinct sub-populations of children, each with distinctive soluble HLA-G evolutions may suggest the existence of groups presenting variable malaria susceptibility. Method: A study was conducted in Benin from 2010 to 2013 and 165 children were followed from birth to 12 months. Evolution of soluble HLA-G was studied by the latent class method. Results: Three groups of children were identified: one with consistently low levels of soluble HLA-G during follow-up, a second with very high levels and a last intermediate group. In all groups, low birth weight, high number of malaria infections and high exposure to malaria transmission were associated with high level of soluble HLA-G. Placental malaria was not. Presence of soluble HLA-G in cord blood increased the probability of belonging to the highest trajectory. Conclusion: These results, together with previous ones, confirm the important role of HLA-G in the individual susceptibility to malaria. Assaying soluble HLA-G at birth could be a good indicator of newborns more fragile and at risk of infections during childhood.
%$ 052