@article{fdi:010066187,
  title = {{E}volution of the levels of human leukocyte antigen {G} ({HLA}-{G}) in {B}eninese infant during the first year of life in a malaria endemic area : using latent class analysis},
  author = {d'{A}lmeida, {T}. {C}. and {S}adissou, {I}. and {C}ottrell, {G}illes and {T}ahar, {R}achida and {M}oreau, {P}. and {F}avier, {B}. and {M}outairou, {K}. and {D}onadi, {E}. {A}. and {M}assougbodji, {A}. and {R}ouass-{F}reiss, {N}. and {C}ourtin, {D}avid and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {HLA}-{G}, a non-classical {HLA} class {I} antigen, is of crucial interest during pregnancy by inhibiting maternal immune response. {I}ts role during infections is discussed, and it has been described that high levels of soluble {HLA}-{G} during childhood increase the risk of malaria. {T}o explore more precisely interactions between soluble {HLA}-{G} and malaria, latent class analysis was used to test whether distinct sub-populations of children, each with distinctive soluble {HLA}-{G} evolutions may suggest the existence of groups presenting variable malaria susceptibility. {M}ethod: {A} study was conducted in {B}enin from 2010 to 2013 and 165 children were followed from birth to 12 months. {E}volution of soluble {HLA}-{G} was studied by the latent class method. {R}esults: {T}hree groups of children were identified: one with consistently low levels of soluble {HLA}-{G} during follow-up, a second with very high levels and a last intermediate group. {I}n all groups, low birth weight, high number of malaria infections and high exposure to malaria transmission were associated with high level of soluble {HLA}-{G}. {P}lacental malaria was not. {P}resence of soluble {HLA}-{G} in cord blood increased the probability of belonging to the highest trajectory. {C}onclusion: {T}hese results, together with previous ones, confirm the important role of {HLA}-{G} in the individual susceptibility to malaria. {A}ssaying soluble {HLA}-{G} at birth could be a good indicator of newborns more fragile and at risk of infections during childhood.},
  keywords = {s{HLA}-{G} ; {E}volution ; {G}roups ; {I}nfancy ; {M}alaria ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {15},
  numero = {},
  pages = {art. 78 [10 p.]},
  ISSN = {1475-2875},
  year = {2016},
  DOI = {10.1186/s12936-016-1131-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066187},
}