Ilboudo H. auteur aut IRD Camara O. auteur aut IRD Ravel Sophie auteur aut IRD Bucheton Bruno auteur aut IRD Lejon Veerle auteur aut IRD Camara M. auteur aut IRD Kabore J. auteur aut IRD Jamonneau Vincent auteur aut IRD Deborggraeve S. auteur aut IRD text journalArticle eng text/pdf born digital access To assess the efficacy of treatment for human African trypanosomiasis, accurate tests that can discriminate relapse from cure are needed. We report the first data that the spliced leader (SL) RNA is a more specific marker for cure of human African trypanosomiasis than parasite DNA. In blood samples obtained from 61 patients in whom human African trypanosomiasis was cured, SL RNA detection had specificities of 98.4%-100%, while DNA detection had a specificity of only 77%. Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure. specialized human African trypanosomiasis diagnosis test of cure RNA specificity GUINEE 052 212 12 1996-1998 2015 0022-1899 https://www.documentation.ird.fr/hor/fdi:010066163 10.1093/infdis/jiv337 0022-1899 [F B010066163] https://www.documentation.ird.fr/hor/fdi:010066163 https://www.documentation.ird.fr/intranet/publi/2016/02/010066163.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2016-02-26 2017-08-23 fdi:010066163 fre