@article{fdi:010065815,
  title = {{C}onfirmation of the use of {L}atex {I}g{M} on cerebrospinal fluid for improving stage determination of {H}uman {A}frican {T}rypanosomiasis},
  author = {{T}ruc, {P}hilippe and {J}amonneau, {V}incent and {G}u{\'e}gan, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he clinical evolution of the chronic form of {H}uman {A}frican {T}rypanosomiasis starts with the haematolymphatic or first stage ({P}1). {T}he meningoencephalitic or second stage ({P}2) begins when trypanosomes reach the cerebrospinal fluid ({CSF}). {T}he classical stage determination method is based on {CSF} cell count, {CSF} protein concentration and/or the presence of trypanosomes detected in {CSF}. {H}owever their cutoff values and the sensitivity of detection of trypanosomes in {CSF} remains doubtful while the appropriate treatment depends on this determination of disease stage. {T}hus, the classical stage determination is reconsidered using new serological tests, and results were compared to the clinical data. {T}hirty-eight patients were classified into 4 clinical groups according to the observed degree of severity of neuropsychiatric signs. {B}ased on multivariate analysis to evaluate the relevance of the new serological tests as compared with clinical groups, we confirm that {L}atex {I}g{M} {CSF}, cheap and easy to perform under field conditions, may improve stage determination of the disease.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{A}frican {J}ournal of {B}iotechnology},
  volume = {4},
  numero = {6},
  pages = {517--521},
  ISSN = {1684-5315},
  year = {2005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065815},
}