Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Xenobiotica 1433-1438 cytochrome P450 CYP CYP2F1 genetic polymorphism inter ethnic variations 2007 fdi:010065793 ENG Xenobiotica 0049-8254 CC:0002518174-0007 12 10.1080/00498250701644403 https://www.documentation.ird.fr/hor/fdi:010065793 https://www.documentation.ird.fr/intranet/publi/depot/2015-10-30/010065793.pdf 37 Horizon (IRD) Since human cytochrome P450 2F1 (CYP2F1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis. The aim of the current study was to compare the frequency of a previously reported frameshift mutation, namely c.14_15insC, responsible for the synthesis of a severely truncated protein, between several populations of different ethnic origins. The frequencies of this polymorphism were 26.1, 51.6, 42.7 and 22.9% in French, Gabonese, Senegalese, and Tunisian population samples, respectively, thereby representing a substantial inter ethnic variation in the CYP2F1 gene. These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity. 050