@article{fdi:010065793,
  title = {{CYP}2{F}1 genetic polymorphism : identification of interethnic variations},
  author = {{T}ournel, {G}. and {C}auffiez, {C}. and {L}eclerc, {J}. and {B}illaut {L}aden, {I}. and {A}llorge, {D}. and {C}hevalier, {D}. and {M}igot {N}abias, {F}lorence and {K}enani, {A}. and {B}roly, {F}. and {L}o {G}uidice, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince human cytochrome {P}450 2{F}1 ({CYP}2{F}1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis. {T}he aim of the current study was to compare the frequency of a previously reported frameshift mutation, namely c.14_15ins{C}, responsible for the synthesis of a severely truncated protein, between several populations of different ethnic origins. {T}he frequencies of this polymorphism were 26.1, 51.6, 42.7 and 22.9% in {F}rench, {G}abonese, {S}enegalese, and {T}unisian population samples, respectively, thereby representing a substantial inter ethnic variation in the {CYP}2{F}1 gene. {T}hese findings provide data for further studies that investigate the potential association of {CYP}2{F}1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity.},
  keywords = {cytochrome {P}450 {CYP} ; {CYP}2{F}1 ; genetic polymorphism ; inter ethnic variations},
  booktitle = {},
  journal = {{X}enobiotica},
  volume = {37},
  numero = {12},
  pages = {1433--1438},
  ISSN = {0049-8254},
  year = {2007},
  DOI = {10.1080/00498250701644403},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065793},
}