%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Konou, A. A.
%A Salou, M.
%A Vidal, Nicole
%A Kodah, P.
%A Kombate, D.
%A Kpanla, P.
%A Nabroulaba, T.
%A Nyametso, D.
%A Singo-Tokofai, A.
%A Pitche, P.
%A Delaporte, Eric
%A Prince-David, M.
%A Peeters, Martine
%A Dagnra, A. Y.
%T Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo
%D 2015
%L fdi:010065519
%G ENG
%J Aids Research and Therapy
%@ 1742-6405
%K HIV ; Antiretroviral treatment ; Drug resistance ; Semi-rural ; Public health ; Togo ; Africa
%K TOGO
%M ISI:000365782000001
%P 38 [8 ]
%R 10.1186/s12981-015-0082-7
%U https://www.documentation.ird.fr/hor/fdi:010065519
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010065519.pdf
%V 12
%W Horizon (IRD)
%X Background: Access to antiretroviral treatment (ART) in resource-limited countries has increased significantly but scaling-up ART into semi-rural and rural areas is more recent. Information on treatment outcome in such areas is still very limited notably due to additional difficulties to manage ART in these areas. Results: 387 HIV-1 infected adults (>= 18 years) were consecutively enrolled when attending healthcare services for their routine medical visit at 12 or 24 months on first-line ART in five HIV care centers (four semi-rural and one rural). Among them, 102 patients were on first-line ART for 12 +/- 2 months (M12) and 285 for 24 +/- 2 months (M24). Virological failure was observed in 70 (18.1 %) patients ranging from 13.9 to 31.6 % at M12 and from 8.1 to 22.4 % at M24 across the different sites. For 67/70 patients, sequencing was successful and drug resistance mutations were observed in 65 (97 %). The global prevalence of drug resistance in the study population was thus at least 16.8 % (65/387). Moreover, 32 (8.3 %) and 27 (6.9 %) patients were either on a completely ineffective ART regime or with only a single drug active. Several patients accumulated high numbers of mutations and developed also cross-resistance to abacavir, didanosine or the new NNRTI drugs like etravirine and rilpivirine. Conclusion: The observations on ART treatment outcome from ART clinics in semi-rural areas are close to previous observations in Lom the capital city suggesting that national ART-programme management plays a role in treatment outcome.
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