Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Aids 1467-1471 HIV-1 mother-to-child-transmission prophylaxis pyrosequencing resistance zidovudine THAILANDE 2015 fdi:010065442 ENG Aids 0269-9370 ISI:000364394500002 12 10.1097/qad.0000000000000737 https://www.documentation.ird.fr/hor/fdi:010065442 https://www.documentation.ird.fr/intranet/publi/2015/12/010065442.pdf 29 Horizon (IRD) To prevent mother-to-child-transmission of HIV-1, the 2010 WHO guidelines recommended prenatal zidovudine (ZDV) monotherapy (option A). To determine if ZDV monotherapy selects for HIV resistance in antiretroviral-naive women during pregnancy, specimens from 50 individuals were examined using pyrosequencing. ZDV-resistance mutations were detected at delivery in seven women (14%, 95% confidence interval 6.6-26.5%). These data raise the question whether women administered ZDV monotherapy for prevention of mother-to-child-transmission could have higher risk of virologic failure when later started on combination antiretroviral therapy, as has been demonstrated following single-dose nevirapine prophylaxis. 052 ; 050 UR174