Mai Tepoerau auteur aut IRD Tintillier T. auteur aut IRD Lucasson A. auteur aut IRD Moriou C. auteur aut IRD Bonno Emile auteur aut IRD Petek Sylvain auteur aut IRD Magré K. auteur aut IRD Al Mourabit A. auteur aut IRD Saulnier D. auteur aut IRD Debitus Cécile auteur aut IRD text journalArticle eng text/pdf born digital access Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known isonaamine A and isonaamidine A. Isonaamidine A and isonaamine D were identified as inhibitors of the three quorum sensing pathways of Vibrio harveyi (CAI-1, AI-2 and harveyi auto inducer), but isonaamidine A displayed the strongest activity on AI-2 biosensor. Both compounds are new examples of natural QSIs of V. harveyi. These results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs. specialized POLYNESIE FRANCAISE PACIFIQUE 034 035 040 61 4 311-317 2015 0266-8254 https://www.documentation.ird.fr/hor/fdi:010064995 10.1111/lam.12461 0266-8254 [F B010064995] https://www.documentation.ird.fr/hor/fdi:010064995 https://www.documentation.ird.fr/intranet/publi/depot/2015-09-29/010064995.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2015-09-29 2015-12-18 fdi:010064995 fre