@article{fdi:010064995,
  title = {{Q}uorum sensing inhibitors from {L}eucetta chagosensis {D}endy, 1863},
  author = {{M}ai, {T}epoerau and {T}intillier, {T}. and {L}ucasson, {A}. and {M}oriou, {C}. and {B}onno, {E}mile and {P}etek, {S}ylvain and {M}agr{\'e}, {K}. and {A}l {M}ourabit, {A}. and {S}aulnier, {D}. and {D}ebitus, {C}{\'e}cile},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ponges are a rich source for investigation of bioactive small molecules. {T}hey have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. {M}icro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. {S}ponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors ({QSI}s). {T}he investigation of the {QSI} crude extract of {L}eucetta chagosensis {D}endy, 1863 led to the isolation of three new alkaloids, isonaamine {D}, di-isonaamidine {A} and leucettamine {D}, along with the known isonaamine {A} and isonaamidine {A}. {I}sonaamidine {A} and isonaamine {D} were identified as inhibitors of the three quorum sensing pathways of {V}ibrio harveyi ({CAI}-1, {AI}-2 and harveyi auto inducer), but isonaamidine {A} displayed the strongest activity on {AI}-2 biosensor. {B}oth compounds are new examples of natural {QSI}s of {V}. harveyi. {T}hese results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs.},
  keywords = {{POLYNESIE} {FRANCAISE} ; {PACIFIQUE}},
  booktitle = {},
  journal = {{L}etters in {A}pplied {M}icrobiology},
  volume = {61},
  numero = {4},
  pages = {311--317},
  ISSN = {0266-8254},
  year = {2015},
  DOI = {10.1111/lam.12461},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064995},
}