@article{fdi:010064908,
  title = {{I}nsights into circulating cytokine dynamics during pregnancy in {HIV}-infected beninese exposed to {P}lasmodium falciparum malaria},
  author = {{I}bitokou, {S}. {A}. and {D}enoeud {N}dam, {L}ise and {E}zinmegnon, {S}. and {L}adekpo, {R}. and {Z}annou, {D}. {M}. and {M}assougbodji, {A}. and {G}irard, {P}. {M}. and {C}ot, {M}ichel and {L}uty, {A}drian and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e investigated the circulating plasma levels of {T}h1- ({I}nterleukin-2 [{IL}-2], tumor necrosis factor-alpha [{TNF}-alpha], interferon-gamma [{IFN}-gamma]) and {T}h2-type (1{L}-4, {IL}-5, {IL}-10) cytokines in human immunodeficiency virus ({HIV})-infected pregnant women living in a malaria-endemic area. {W}e analyzed samples from 200 pregnant women included in the prevention of pregnancy-associated malaria in {HIV}-infected women: cotrimoxazole prophylaxis versus mefloquine ({PACOME}) clinical trial who were followed until delivery. {C}ytokine concentrations were measured by flow cytometry-based multiplex bead array. {S}ignificantly elevated levels of {IL}-10 and lower levels of {TNF}-alpha were observed at delivery compared with inclusion ({P} = 0.005). {A}t inclusion, the presence of circulating 1{FN}-gamma, a higher {CD}4(+) {T} cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine ({SP}-{IPT}p) were all associated with a lower likelihood of {P}lasmodium falciparum infection. {A}t delivery, the inverse relationship between the presence of infection and circulating {IFN}-gamma persisted, although there was a positive association between the likelihood of infection and the presence of circulating {TNF}-alpha. {I}nitiation of antiretroviral therapy was associated with elevated {IL}-5 production. {C}onsistent with our own and others' observations in {HIV} seronegative subjects, this study shows circulating {IL}-10 to be a marker of infection with {P}. falciparum during pregnancy even in {HIV}-infected women, although plasma {IFN}-gamma may be a marker of anti-malarial protection in such women.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {93},
  numero = {2},
  pages = {287--292},
  ISSN = {0002-9637},
  year = {2015},
  DOI = {10.4269/ajtmh.14-0653},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064908},
}