@article{fdi:010064725,
  title = {{E}lectrophysiological and behavioral characterization of bioactive compounds of the {T}hymus vulgaris, {C}ymbopogon winterianus, {C}uminum cyminum and {C}innamomum zeylanicum essential oils against {A}nopheles gambiae and prospects for their use as bednet treatments},
  author = {{D}eletre, {E}. and {C}handre, {F}abrice and {W}illiams, {L}. and {D}umenil, {C}. and {M}enut, {C}. and {M}artin, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {L}aboratory and field studies showed that repellent, irritant and toxic actions of common public health insecticides reduce human-vector contact and thereby interrupt disease transmission. {O}ne of the more effective strategies to reduce disease risk involves the use of long-lasting treated bednets. {H}owever, development of insecticide resistance in mosquito populations makes it imperative to find alternatives to these insecticides. {O}ur previous study identified four essential oils as alternatives to pyrethroids: {T}hymus vulgaris, {C}ymbopogon winterianus, {C}uminum cyminum, {C}innamomum zeylanicum. {T}he objectives of this study were to identify active compounds of these essential oils, to characterize their biological activity, and to examine their potential as a treatment for bednets. {M}ethods: {W}e evaluated the electrophysiological, behavioural (repellency, irritancy) and toxic effects of the major compounds of these oils against {A}nopheles gambiae strain '{K}isumu'. {R}esults: {A}ldehydes elicited the strongest responses and monoterpenes the weakest responses in electroantennogram ({EAG}) trials. {H}owever, {EAG} responses did not correlate consistently with results of behavioral assays. {I}n behavioral and toxicity studies, several of the single compounds did exhibit repellency, irritancy or toxicity in {A}n. gambiae; however, the activity of essential oils did not always correlate with activity expected from the major components. {O}n the contrary, the biological activity of essential oils appeared complex, suggesting interactions between individual compounds and the insect under study. {D}ata also indicated that the three effects appeared independent, suggesting that repellency mechanism(s) may differ from mechanisms of irritancy and toxicity. {C}onclusions: {B}ased on the bioassays reported here, some of the compounds merit consideration as alternative bednet treatments.},
  keywords = {{E}ssential oil ; {R}epellency ; {T}oxicity ; {V}ector control ; {DEET} ; {P}ermethrin},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {8},
  numero = {},
  pages = {316 [14 ]},
  ISSN = {1756-3305},
  year = {2015},
  DOI = {10.1186/s13071-015-0934-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064725},
}