%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A VanBuren, R.
%A Zeng, F. C.
%A Chen, C. X.
%A Zhang, J. S.
%A Wai, C. M.
%A Han, J.
%A Aryal, R.
%A Gschwend, A. R.
%A Wang, J. P.
%A Na, J. K.
%A Huang, L. X.
%A Zhang, L. M.
%A Miao, W. J.
%A Gou, J. Q.
%A Arro, J.
%A Guyot, Romain
%A Moore, R. C.
%A Wang, M. L.
%A Zee, F.
%A Charlesworth, D.
%A Moore, P. H.
%A Yu, Q. Y.
%A Ming, R.
%T Origin and domestication of papaya Y-h chromosome
%D 2015
%L fdi:010064149
%G ENG
%J Genome Research
%@ 1088-9051
%K AMERIQUE CENTRALE ; COSTA RICA
%M ISI:000352139200007
%N 4
%P 524-533
%R 10.1101/gr.183905.114
%U https://www.documentation.ird.fr/hor/fdi:010064149
%> https://www.documentation.ird.fr/intranet/publi/2015/05/010064149.pdf
%V 25
%W Horizon (IRD)
%X Sex in papaya is controlled by a pair of nascent sex chromosomes. Females are XX, and two slightly different Y chromosomes distinguish males (XY) and hermaphrodites (XYh). The hermaphrodite-specific region of the Yh chromosome (HSY) and its X chromosome counterpart were sequenced and analyzed previously. We now report the sequence of the entire male-specific region of the Y (MSY). We used a BAC-by-BAC approach to sequence the MSY and resequence the Y regions of 24 wild males and the Y-h regions of 12 cultivated hermaphrodites. The MSY and HSY regions have highly similar gene content and structure, and only 0.4% sequence divergence. The MSY sequences from wild males include three distinct haplotypes, associated with the populations' geographic locations, but gene flow is detected for other genomic regions. The Y-h sequence is highly similar to one Y haplotype (MSY3) found only in wild dioecious populations from the north Pacific region of Costa Rica. The low MSY3-Y-h divergence supports the hypothesis that hermaphrodite papaya is a product of human domestication. We estimate that Y-h arose only similar to 4000 yr ago, well after crop plant domestication in Mesoamerica >6200 yr ago but coinciding with the rise of the Maya civilization. The Y-h chromosome has lower nucleotide diversity than the Y, or the genome regions that are not fully sex-linked, consistent with a domestication bottleneck. The identification of the ancestral MSY3 haplotype will expedite investigation of the mutation leading to the domestication of the hermaphrodite Y-h chromosome. In turn, this mutation should identify the gene that was affected by the carpel-suppressing mutation that was involved in the evolution of males.
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