@article{fdi:010064149,
  title = {{O}rigin and domestication of papaya {Y}-h chromosome},
  author = {{V}an{B}uren, {R}. and {Z}eng, {F}. {C}. and {C}hen, {C}. {X}. and {Z}hang, {J}. {S}. and {W}ai, {C}. {M}. and {H}an, {J}. and {A}ryal, {R}. and {G}schwend, {A}. {R}. and {W}ang, {J}. {P}. and {N}a, {J}. {K}. and {H}uang, {L}. {X}. and {Z}hang, {L}. {M}. and {M}iao, {W}. {J}. and {G}ou, {J}. {Q}. and {A}rro, {J}. and {G}uyot, {R}omain and {M}oore, {R}. {C}. and {W}ang, {M}. {L}. and {Z}ee, {F}. and {C}harlesworth, {D}. and {M}oore, {P}. {H}. and {Y}u, {Q}. {Y}. and {M}ing, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ex in papaya is controlled by a pair of nascent sex chromosomes. {F}emales are {XX}, and two slightly different {Y} chromosomes distinguish males ({XY}) and hermaphrodites ({XY}h). {T}he hermaphrodite-specific region of the {Y}h chromosome ({HSY}) and its {X} chromosome counterpart were sequenced and analyzed previously. {W}e now report the sequence of the entire male-specific region of the {Y} ({MSY}). {W}e used a {BAC}-by-{BAC} approach to sequence the {MSY} and resequence the {Y} regions of 24 wild males and the {Y}-h regions of 12 cultivated hermaphrodites. {T}he {MSY} and {HSY} regions have highly similar gene content and structure, and only 0.4% sequence divergence. {T}he {MSY} sequences from wild males include three distinct haplotypes, associated with the populations' geographic locations, but gene flow is detected for other genomic regions. {T}he {Y}-h sequence is highly similar to one {Y} haplotype ({MSY}3) found only in wild dioecious populations from the north {P}acific region of {C}osta {R}ica. {T}he low {MSY}3-{Y}-h divergence supports the hypothesis that hermaphrodite papaya is a product of human domestication. {W}e estimate that {Y}-h arose only similar to 4000 yr ago, well after crop plant domestication in {M}esoamerica >6200 yr ago but coinciding with the rise of the {M}aya civilization. {T}he {Y}-h chromosome has lower nucleotide diversity than the {Y}, or the genome regions that are not fully sex-linked, consistent with a domestication bottleneck. {T}he identification of the ancestral {MSY}3 haplotype will expedite investigation of the mutation leading to the domestication of the hermaphrodite {Y}-h chromosome. {I}n turn, this mutation should identify the gene that was affected by the carpel-suppressing mutation that was involved in the evolution of males.},
  keywords = {{AMERIQUE} {CENTRALE} ; {COSTA} {RICA}},
  booktitle = {},
  journal = {{G}enome {R}esearch},
  volume = {25},
  numero = {4},
  pages = {524--533},
  ISSN = {1088-9051},
  year = {2015},
  DOI = {10.1101/gr.183905.114},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064149},
}