@article{fdi:010064139,
  title = {{B}ehavioral cost and overdominance in {A}nopheles gambiae},
  author = {{D}iop, {M}. {M}. and {M}oiroux, {N}icolas and {C}handre, {F}abrice and {M}artin-{H}errou, {H}. and {M}ilesi, {P}. and {B}oussari, {O}. and {P}orciani, {A}ng{\'e}lique and {D}uchon, {S}t{\'e}phane and {L}abbe, {P}. and {P}ennetier, {C}{\'e}dric},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n response to the widespread use of control strategies such as {I}nsecticide {T}reated {N}ets ({ITN}), {A}nopheles mosquitoes have evolved various resistance mechanisms. {K}dr is a mutation that provides physiological resistance to the pyrethroid insecticides family ({PYR}). {I}n the present study, we investigated the effect of the {K}dr mutation on the ability of female {A}n. gambiae to locate and penetrate a 1cm-diameter hole in a piece of netting, either treated with insecticide or untreated, to reach a bait in a wind tunnel. {K}dr homozygous, {PYR}-resistant mosquitoes were the least efficient at penetrating an untreated damaged net, with about 51% [39-63] success rate compared to 80% [70-90] and 78% [65-91] for homozygous susceptible and heterozygous respectively. {T}his reduced efficiency, likely due to reduced host- seeking activity, as revealed by mosquito video-tracking, is evidence of a recessive behavioral cost of the mutation. {K}dr heterozygous mosquitoes were the most efficient at penetrating nets treated with {PYR} insecticide, thus providing evidence for overdominance, the rarely-described case of heterozygote advantage conveyed by a single locus. {T}he study also highlights the remarkable capacity of female mosquitoes, whether {PYR}-resistant or not, to locate holes in bed-nets.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {10},
  numero = {4},
  pages = {e0121755 [12 p.]},
  ISSN = {1932-6203},
  year = {2015},
  DOI = {10.1371/journal.pone.0121755},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064139},
}