@article{fdi:010063634,
  title = {{D}ifferences in gene transcriptomic pattern of {P}lasmodium falciparum in children with cerebral malaria and asymptomatic carriers},
  author = {{A}lmelli, {T}. and {N}uel, {G}. and {B}ischoff, {E}. and {A}ubouy, {A}gn{\`e}s and {E}lati, {M}. and {W}ang, {C}. {W}. and {D}illies, {M}. {A}. and {C}oppee, {J}. {Y}. and {A}yissi, {G}. {N}. and {B}asco, {L}eonardo and {R}ogier, {C}. and {T}uikue {N}dam, {N}icaise and {D}eloron, {P}hilippe and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he mechanisms underlying the heterogeneity of clinical malaria remain largely unknown. {W}e hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in a specific interaction with the host, leading to different clinical features of malaria. {I}n this study, we analyzed the transcriptomes of isolates obtained from asymptomatic carriers and patients with uncomplicated or cerebral malaria. {W}e also investigated the transcriptomes of 3{D}7 clone and 3{D}7-{L}ib that expresses severe malaria associated-variant surface antigen. {O}ur findings revealed a specific up-regulation of genes involved in pathogenesis, adhesion to host cell, and erythrocyte aggregation in parasites from patients with cerebral malaria and 3{D}7-{L}ib, compared to parasites from asymptomatic carriers and 3{D}7, respectively. {H}owever, we did not find any significant difference between the transcriptomes of parasites from cerebral malaria and uncomplicated malaria, suggesting similar transcriptomic pattern in these two parasite populations. {T}he difference between isolates from asymptomatic children and cerebral malaria concerned genes coding for exported proteins, {M}aurer's cleft proteins, transcriptional factor proteins, proteins implicated in protein transport, as well as {P}lasmodium conserved and hypothetical proteins. {I}nterestingly, {UP}s {A}1, {A}2, {A}3 and {UP}s {B}1 of var genes were predominantly found in cerebral malaria-associated isolates and those containing architectural domains of {DC}4, {DC}5, {DC}13 and their neighboring rif genes in 3{D}7-lib. {T}herefore, more investigations are needed to analyze the effective role of these genes during malaria infection to provide with new knowledge on malaria pathology. {I}n addition, concomitant regulation of genes within the chromosomal neighborhood suggests a common mechanism of gene regulation in {P}. falciparum.},
  keywords = {{CAMEROUN} ; {BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {12},
  pages = {e114401 [23 p.]},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0114401},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063634},
}