@article{fdi:010063089,
  title = {{R}andomized trial of artesunate-amodiaquine, atovaquone-proguanil, and artesunate-atovaquone-proguanil for the treatment of uncomplicated falciparum malaria in children},
  author = {{T}ahar, {R}achida and {A}lmelli, {T}. and {D}ebue, {C}. and {N}gane, {V}. {F}. and {A}llico, {J}. {D}. and {Y}oudom, {S}. {W}. and {B}asco, {L}eonardo},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rtemisinin-based combination therapies ({ACT}s) are recommended for the treatment of acute uncomplicated falciparum malaria in many malaria-endemic countries. {D}espite the emergence of artemisinin resistance, few alternative non-{ACT}s, including atovaquone-proguanil, are currently available. {P}lasmodium falciparum-infected {C}ameroonian children a parts per thousand currency sign5 years old (n = 338) were randomly assigned to artesunate-amodiaquine, atovaquone-proguanil, or artesunate-atovaquone-proguanil treatment groups and followed for 28 days, according to the standard {W}orld {H}ealth {O}rganization protocol. {I}n vitro response to atovaquone and cytochrome b sequence of clinical isolates were determined. {E}ight late failures and 16 failures (8 late and 8 early failures) were observed after artesunate-amodiaquine and atovaquone-proguanil therapies, respectively. {M}ost late failures were due to reinfections. {A}rtesunate-atovaquone-proguanil was not associated with any failure. {A}fter correction by genotyping, per-protocol analysis showed no difference in the efficacy of 3 drugs. {H}owever, the proportion of atovaquone-proguanil-treated patients with positive smears on day 3 was much higher (36.0%; {P} < .05) than that of the artesunate-amodiaquine (2.9%) and artesunate-atovaquone-proguanil (1.0%) groups. {I}n vitro response and cytochrome b sequence did not indicate atovaquone resistance. {A}tovaquone-proguanil was characterized by a slow blood schizontocidal action and resulted in early treatment failure in a few patients. {A}rtesunate-atovaquone-proguanil was a highly effective alternative treatment. {UMIN}000003813.},
  keywords = {drug resistance ; {P}lasmodium falciparum ; cytochrome b ; artemisinin ; molecular epidemiology ; {CAMEROUN}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {210},
  numero = {12},
  pages = {1962--1971},
  ISSN = {0022-1899},
  year = {2014},
  DOI = {10.1093/infdis/jiu341},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063089},
}