Briant L. auteur aut IRD Desprès P. auteur aut IRD Choumet V. auteur aut IRD Missé Dorothée auteur aut IRD text journalArticle eng text/pdf born digital access Due to climate change and the propagation of competent arthropods worldwide, arboviruses have become pathogens of major medical importance. Early transmission to vertebrates is initiated by skin puncture and deposition of virus together with arthropod saliva in the epidermis and dermis. Saliva components have the capacity to modulate skin cell responses by enhancing and/or counteracting initial replication and establishment of systemic viral infection. Here, we review the nature of the cells targeted by arboviruses at the skin level and discuss the type of cellular responses elicited by these pathogens in light of the immunomodulatory properties of arthropod vector-derived salivary factors injected at the inoculation site. Understanding cutaneous arbovirus–host interactions may provide new clues for the design of future therapeutics. specialized ARBOVIROSE DENGUE TRANSMISSION VECTEUR MOUSTIQUE AGENT PATHOGENE IMMUNITE ETUDE EXPERIMENTALE CHIKUNGUNYA SALIVE PIQURE PEAU EPIDERME DERME ZONE TROPICALE 052CULARB04 464-465 26-32 2014 0042-6822 https://www.documentation.ird.fr/hor/fdi:010062803 10.1016/j.virol.2014.06.023 0042-6822 [F B010062803] https://www.documentation.ird.fr/hor/fdi:010062803 https://www.documentation.ird.fr/intranet/publi/depot/2014-08-21/010062803.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2014-08-21 2015-01-17 fdi:010062803 fre