Alout H. auteur aut IRD Yameogo B. auteur aut IRD Djogbénou L. S. auteur aut IRD Chandre Fabrice auteur aut IRD Dabiré R. K. auteur aut IRD Corbel Vincent auteur aut IRD Cohuet Anna auteur aut IRD text journalArticle eng text/pdf born digital access Despite its epidemiological importance, the impact of insecticide resistance on vector-parasite interactions and malaria transmission is poorly understood. Here, we explored the impact of Plasmodium infection on the level of insecticide resistance to dichlorodiphenyltrichloroethane (DDT) in field-caught Anopheles gambiae sensu stricto homozygous for the kdr mutation. Results showed that kdr homozygous mosquitoes that fed on infectious blood were more susceptible to DDT than mosquitoes that fed on noninfectious blood during both ookinete development (day 1 after the blood meal) and oocyst maturation (day 7 after the blood meal) but not during sporozoite invasion of the salivary glands. Plasmodium falciparum infection seemed to impose a fitness cost on mosquitoes by reducing the ability of kdr homozygous A. gambiae sensu stricto to survive exposure to DDT. These results suggest an interaction between Plasmodium infection and the insecticide susceptibility of mosquitoes carrying insecticide-resistant alleles. We discuss this finding in relation to vector control efficacy. specialized malaria cost of infection Anopheles gambiae insecticide exposure kdr insecticide resistance Plasmodium falciparum BURKINA FASO 052 020 210 9 1464-1470 2014 0022-1899 https://www.documentation.ird.fr/hor/fdi:010062710 10.1093/infdis/jiu276 0022-1899 [F B010062710] https://www.documentation.ird.fr/hor/fdi:010062710 https://www.documentation.ird.fr/intranet/publi/2014/12/010062710.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2015-01-12 2017-08-23 fdi:010062710 fre