Vidal-Dupiol J. auteur aut IRD Dheilly N. M. auteur aut IRD Rondon R. auteur aut IRD Grunau C. auteur aut IRD Cosseau C. auteur aut IRD Smith K. M. auteur aut IRD Freitag M. auteur aut IRD Adjeroud Mehdi auteur aut IRD Mitta G. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase on immunity and pathogen virulence have been clearly identified, their interaction, synergy and relative weight during pathogenesis remain poorly documented. We investigated these phenomena in the interaction between the coral Pocillopora damicornis and the bacterium Vibrio coralliilyticus, for which the infection process is temperature-dependent. We developed an experimental model that enabled unraveling the effects of thermal stress, and virulence vs. non-virulence of the bacterium. The physiological impacts of various treatments were quantified at the transcriptome level using a combination of RNA sequencing and targeted approaches. The results showed that thermal stress triggered a general weakening of the coral, making it more prone to infection, non-virulent bacterium induced an 'efficient' immune response, whereas virulent bacterium caused immuno-suppression in its host. specialized OCEAN INDIEN OCEAN PACIFIQUE INDONESIE 034 020 021 9 9 art. e107672 [15 ] 2014 1932-6203 https://www.documentation.ird.fr/hor/fdi:010062587 10.1371/journal.pone.0107672 1932-6203 [F B010062587] https://www.documentation.ird.fr/hor/fdi:010062587 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-08/010062587.pdf IRD - Base Horizon / Pleins textes 2014-12-05 2017-09-06 fdi:010062587 fre