@article{fdi:010062233,
  title = {{P}revalence of the sickle cell trait in {G}abon : a nationwide study},
  author = {{D}elicat-{L}oembet, {L}. {M}. and {E}lguero, {E}ric and {A}rnathau, {C}. and {D}urand, {P}. and {O}llomo, {B}. and {O}ssari, {S}. and {M}ezui-{M}e-{N}dong, {J}. and {M}boro, {T}. {M}. and {B}ecquart, {P}ierre and {N}koghe, {D}. and {L}eroy, {E}ric and {S}ica, {L}. and {G}onzalez, {J}ean-{P}aul and {P}rugnolle, {F}ranck and {R}enaud, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ickle {C}ell {D}isease ({SCD}) is an important cause of death in young children in {A}frica, which the {W}orld {H}ealth {O}rganization has declared a public health priority. {A}lthough {SCD} has been studied at the continental scale and at the local scale, a picture of its distribution at the scale of an {A}frican country has never been given. {T}he aim of this study is to provide such a picture for the {R}epublic of {G}abon, a country where precisely the epidemiology of {SCD} has been poorly investigated. {T}o this effect, 4250 blood samples from persons older than 15 were collected between {J}une 2005 and {S}eptember 2008 in 210 randomly selected villages from the nine administrative provinces of {G}abon. {T}wo methods were used to screen {S}ickle {C}ell {T}rait ({SCT}) carriers: isoelectric focusing ({IEF}) and high-performance liquid chromatography ({HPLC}). {SCT} prevalence in {G}abon was 21.1% (895/4249). {SCT} prevalence was significantly larger for the {B}antu population (21.7%, n = 860/3959) than for the {P}ygmy population (12.1%, n = 35/290), (p = 0.00013). {I}n addition, the presence of {P}lasmodium sp. was assessed via thick blood examination. {A}ge was positively associated with {SCT} prevalence (odds-ratio for an increase of 10 years in age = 1.063, p = 0.020). {S}ex was not associated with {SCT} prevalence. {T}he study reveals the absence of homozygous sickle-cell patients, and marked differences in {SCT} prevalence between the {G}abonese provinces, and also between population groups ({B}antu vs {P}ygmy). {T}hese findings could be used by the public health authorities to allocate medical resources and target prevention campaigns.},
  keywords = {{S}ickle {C}ell {D}isease ; {P}ygmy ; {B}antu ; {G}abon ; {E}cology ; {E}volution ; {GABON}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {25},
  numero = {},
  pages = {52--56},
  ISSN = {1567-1348},
  year = {2014},
  DOI = {10.1016/j.meegid.2014.04.003},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062233},
}