@article{fdi:010061826,
  title = {{W}orldwide genetic variation at the 3 ' untranslated region of the {HLA}-{G} gene : balancing selection influencing genetic diversity},
  author = {{S}abbagh, {A}. and {L}uisi, {P}. and {C}astelli, {E}. {C}. and {G}ineau, {L}aure and {C}ourtin, {D}avid and {M}ilet, {J}acqueline and {M}assaro, {J}. {D}. and {L}aayouni, {H}. and {M}oreau, {P}. and {D}onadi, {E}. {A}. and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {HLA}-{G} (human leukocyte antigen-{G}) molecule plays a pivotal role in immune tolerance by inhibiting different cell subsets involved in both innate and adaptive immunity. {B}esides its primary function in maintaining the maternal-fetal tolerance, {HLA}-{G} has been involved in a wide range of pathological conditions where it can be either favorable or detrimental to the patient, depending on the nature of the pathology. {A}lthough several studies have demonstrated the utmost importance of the 30 untranslated region (3'{UTR}) in the {HLA}-{G} expression profile, limited data exist on the sequence variability of this gene region in human populations. {I}n this study, we characterized the genetic diversity and haplotype structure of the {HLA}-{G} 3'{UTR} by resequencing 444 individuals from three sub-{S}aharan {A}frican populations and retrieving data from the 1000 {G}enomes project and the literature. {A} total of 1936 individuals representing 21 worldwide populations were combined and jointly analyzed. {O}ur data revealed a high level of nucleotide diversity, an excess of intermediate frequency variants and an extremely low population differentiation, strongly supporting a history of balancing selection at this locus. {T}he 14-bp insertion/deletion polymorphism was further pointed out as the likely target of selection, emphasizing its potential role in the post-transcriptional regulation of {HLA}-{G} expression.},
  keywords = {{HLA}-{G} ; 3 ' {UTR} ; haplotype ; linkage disequilibrium ; balancing selection ; evolution},
  booktitle = {},
  journal = {{G}enes and {I}mmunity},
  volume = {15},
  numero = {2},
  pages = {95--106},
  ISSN = {1466-4879},
  year = {2014},
  DOI = {10.1038/gene.2013.67},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061826},
}