@article{fdi:010061735,
  title = {{A}ssociation mapping, patterns of linkage disequilibrium and selection in the vicinity of the phytochrome {C} gene in pearl millet},
  author = {{S}aidou, {A}. {A}. and {C}lotault, {J}. and {C}ouderc, {M}arie and {M}ariac, {C}{\'e}dric and {D}evos, {K}. {M}. and {T}huillet, {A}nne-{C}{\'e}line and {A}moukou, {I}. {A}. and {V}igouroux, {Y}ves},
  editor = {},
  language = {{ENG}},
  abstract = {{K}ey message {L}inkage analysis confirmed the association in the region of {PHYC} in pearl millet. {T}he comparison of genes found in this region suggests that {PHYC} is the best candidate. {M}ajor efforts are currently underway to dissect the phenotype-genotype relationship in plants and animals using existing populations. {T}his method exploits historical recombinations accumulated in these populations. {H}owever, linkage disequilibrium sometimes extends over a relatively long distance, particularly in genomic regions containing polymorphisms that have been targets for selection. {I}n this case, many genes in the region could be statistically associated with the trait shaped by the selected polymorphism. {S}tatistical analyses could help in identifying the best candidate genes into such a region where an association is found. {I}n a previous study, we proposed that a fragment of the {PHYTOCHROME} {C} gene ({PHYC}) is associated with flowering time and morphological variations in pearl millet. {I}n the present study, we first performed linkage analyses using three pearl millet {F}-2 families to confirm the presence of a {QTL} in the vicinity of {PHYC}. {W}e then analyzed a wider genomic region of similar to 100 kb around {PHYC} to pinpoint the gene that best explains the association with the trait in this region. {A} panel of 90 pearl millet inbred lines was used to assess the association. {W}e used a {M}arkov chain {M}onte {C}arlo approach to compare 75 markers distributed along this 100-kb region. {W}e found the best candidate markers on the {PHYC} gene. {S}ignatures of selection in this region were assessed in an independent data set and pointed to the same gene. {T}hese results foster confidence in the likely role of {PHYC} in phenotypic variation and encourage the development of functional studies.},
  keywords = {{NIGER}},
  booktitle = {},
  journal = {{T}heoretical and {A}pplied {G}enetics},
  volume = {127},
  numero = {1},
  pages = {19--32},
  ISSN = {0040-5752},
  year = {2014},
  DOI = {10.1007/s00122-013-2197-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061735},
}