@article{fdi:010061570,
  title = {{D}ramatic declines in seropositivity as determined with crude extracts of {P}lasmodium falciparum schizonts between 2000 and 2010 in {D}ielmo and {N}diop, {S}enegal},
  author = {{D}iop, {F}. and {R}ichard, {V}. and {S}okhna, {C}heikh and {D}iagne, {N}afissatou and {T}rape, {J}ean-{F}ran{\c{c}}ois and {F}aye, {M}.{M}. and {T}all, {A}. and {T}oure {B}alde, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {P}rogrammes of pre-elimination of malaria have been implemented in {S}enegal since 2010, and the burden of malaria has decreased substantially. {T}hese changes in the epidemiology should be monitored with effective tools that allow changes in patterns of transmission to be estimated. {I}n {D}ielmo and {N}diop, two villages of {S}enegal with different malaria endemicity, infections have been followed longitudinally for 20 years, during which time there have been several control interventions leading to substantial decreases of transmission. {T}his study aimed to compare malaria antibody responses of the inhabitants of these two villages, between 2000 and 2010, using schizont crude extracts of a local strain of {P}. falciparum ({P}f {S}ch07/03). {METHODS}: {S}era collected from inhabitants of the two villages (141 from {D}ielmo and 79 from {N}diop in 2000; 143 from {D}ielmo and 79 from {N}diop in 2010) were used to assess the prevalence of antibodies against crude schizont extracts of {P}f {S}ch07/03. {T}hree ages groups were defined: [5-9] yrs, [10-14] yrs and [15-19] yrs. {S}tatistical comparisons were performed. {S}eroprevalence and the magnitude of antibody responses were compared between age groups, villages and periods. {RESULTS}: {O}verall seroprevalence to {P}.f{S}ch07/03 decreased between 2000 and 2010 in both villages: from 94.4% to 44.4% in {D}ielmo and from 74.4% to 34.6% in {N}diop. {T}he difference between {D}ielmo and {N}diop was highly significant in 2000 (p<0.001) but not in 2010 (p >0.20). {T}he decrease in seroprevalence was larger in younger (more than 40%) than older (less than 19%) inhabitants. {L}ongitudinal monitoring of the younger group showed that seroprevalence decreased between 2000 and 2010 in {D}ielmo from 98.7 to 79.3, but not in {N}diop from 67.6 to 66.7. {T}he magnitude of antibody responses in seropositive individuals was significantly higher in 2000 than 2010 for both villages. {CONCLUSIONS}: {C}rude extracts of {P}. falciparum are appropriate tools for evaluating malaria prevalence at different periods, and in both low and high endemic area. {U}sing crude extracts from local strains to assess transmission may allow efficient evaluation of the consequences of control programs on malaria transmission.},
  keywords = {{PALUDISME} ; {EPIDEMIOLOGIE} ; {SEROLOGIE} ; {PREVALENCE} ; {ANTICORPS} ; {DIAGNOSTIC} ; {ENFANT} ; {MILIEU} {RURAL} ; {VILLAGE} ; {LUTTE} ; {METHODOLOGIE} ; {SENEGAL} ; {DIELMO} ; {NDIOP}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {13},
  numero = {1},
  pages = {83 [8  en ligne]},
  ISSN = {1475-2875},
  year = {2014},
  DOI = {10.1186/1475-2875-13-83},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061570},
}