Pennetier Cédric auteur aut IRD Bouraima A. auteur aut IRD Chandre Fabrice auteur aut IRD Piameu M. auteur aut IRD Etang J. auteur aut IRD Rossignol M. auteur aut IRD Sidick I. auteur aut IRD Zogo B. auteur aut IRD Lacroix Marie-Noëlle auteur aut IRD Yadav R. auteur aut IRD Pigeon O. auteur aut IRD Corbel Vincent auteur aut IRD text journalArticle eng text/pdf reformatted digital access Due to the rapid extension of pyrethroid resistance in malaria vectors worldwide, manufacturers are developing new vector control tools including insecticide mixtures containing at least two active ingredients with different mode of action as part of insecticide resistance management. Olyset (R) Plus is a new long-lasting insecticidal net (LLIN) incorporating permethrin and a synergist, piperonyl butoxide (PBO), into its fibres in order to counteract metabolic-based pyrethroid resistance of mosquitoes. In this study, we evaluated the efficacy of Olyset (R) Plus both in laboratory and field against susceptible and multi-resistant malaria vectors and compared with Olyset (R) Net, which is a permethrin incorporated into polyethylene net. In laboratory, Olyset (R) Plus performed better than Olyset (R) Net against susceptible Anopheles gambiae strain with a 2-day regeneration time owing to an improved permethrin bleeding rate with the new incorporation technology. It also performed better than Olyset (R) Net against multiple resistant populations of An. gambiae in experimental hut trials in West Africa. Moreover, the present study showed evidence for a benefit of incorporating a synergist, PBO, with a pyrethroid insecticide into mosquito netting. These results need to be further validated in a large-scale field trial to assess the durability and acceptability of this new tool for malaria vector control. specialized AFRIQUE DE L'OUEST 052 8 10 e75134 2013 1932-6203 https://www.documentation.ird.fr/hor/fdi:010061207 10.1371/journal.pone.0075134 1932-6203 [F B010061207] https://www.documentation.ird.fr/hor/fdi:010061207 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010061207.pdf IRD - Base Horizon / Pleins textes 2013-12-02 2017-10-31 fdi:010061207 fre