Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Parasites and Vectors 68 Malaria Salivary peptide Biomarker Low transmission Anopheles exposure Antibodies SENEGAL 2013 fdi:010060845 ENG Parasites and Vectors 1756-3305 ISI:000317826800001 10.1186/1756-3305-6-68 https://www.documentation.ird.fr/hor/fdi:010060845 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010060845.pdf 6 Horizon (IRD) Background: Over the past decade, a sharp decline of malaria burden has been observed in several countries. Consequently, the conventional entomological methods have become insufficiently sensitive and probably underestimate micro-geographical heterogeneity of exposure and subsequent risk of malaria transmission. In this study, we investigated whether the human antibody (Ab) response to Anopheles salivary gSG6-P1 peptide, known as a biomarker of Anopheles exposure, could be a sensitive and reliable tool for discriminating human exposure to Anopheles bites in area of low and seasonal malaria transmission. Methods: A multi-disciplinary survey was performed in Northern Senegal where An. gambiae s.l. is the main malaria vector. Human IgG Ab response to gSG6-P1 salivary peptide was compared according to the season and villages in children from five villages in the middle Senegal River valley, known as a low malaria transmission area. Results: IgG levels to gSG6-P1 varied considerably according to the villages, discriminating the heterogeneity of Anopheles exposure between villages. Significant increase of IgG levels to gSG6-P1 was observed during the peak of exposure to Anopheles bites, and decreased immediately after the end of the exposure season. In addition, differences in the season-dependent specific IgG levels between villages were observed after the implementation of Long-Lasting Insecticidal Nets by The National Malaria Control Program in this area. Conclusion: The gSG6-P1 salivary peptide seems to be a reliable tool to discriminate the micro-geographical heterogeneity of human exposure to Anopheles bites in areas of very low and seasonal malaria transmission. A biomarker such as this could also be used to monitor and evaluate the possible heterogeneous effectiveness of operational vector control programs in low-exposure areas. 052 ; 050 ; 020 UR224 / UR198 Sénégal