@article{fdi:010060813,
  title = {{R}eproductive isolation and local adaptation quantified for a chromosome inversion in a malaria mosquito},
  author = {{A}yala, {D}iego and {G}uerrero, {R}. {F}. and {K}irkpatrick, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hromosome inversions have long been thought to be involved in speciation and local adaptation. {W}e have little quantitative information, however, about the effects that inversion polymorphisms have on reproductive isolation and viability. {H}ere we provide the first estimates from any organism for the total amount of reproductive isolation associated with an inversion segregating in natural populations. {W}e sampled chromosomes from 751 mosquitoes of the malaria vector {A}nopheles funestus along a 1421 km transect in {C}ameroon that traverses savannah, highland, and rainforest ecological zones. {W}e then developed a series of population genetic models that account for selection, migration, and assortative mating, and fit the models to the data using likelihood. {R}esults from the best-fit models suggest there is strong local adaptation, with relative viabilities of homozygotes ranging from 25% to 130% compared to heterozygotes. {V}iabilities vary qualitatively between regions: the inversion is underdominant in the savannah, whereas in the highlands it is overdominant. {T}he inversion is also implicated in strong assortative mating. {I}n the savannah, the two homozygote forms show 92% reproductive isolation, suggesting that this one inversion can generate most of the genetic barriers needed for speciation.},
  keywords = {{A}nopheles ; assortative mating ; selection ; postzygotic ; prezygotic ; speciation ; {CAMEROUN}},
  booktitle = {},
  journal = {{E}volution},
  volume = {67},
  numero = {4},
  pages = {946--958},
  ISSN = {0014-3820},
  year = {2013},
  DOI = {10.1111/j.1558-5646.2012.01836.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060813},
}