@article{fdi:010060700,
  title = {{E}valuation of compliance to congenital {C}hagas disease treatment : results of a randomised trial in {B}olivia},
  author = {{C}hippaux, {J}ean-{P}hilippe and {S}alas-{C}lavijo, {A}. {N}. and {P}ostigo, {J}. {R}. and {S}chneider, {D}ominique and {S}antalla, {J}. {A}. and {B}rutus, {L}aurent},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A} randomised, unblinded, clinical trial comparing two benznidazole regimens for congenital {C}hagas disease was carried out to determine whether simplification and reduction in the length of treatment could lead to better treatment compliance. {M}ethods: {T}his study was conducted in {S}anta {C}ruz, {B}olivia. {S}erological screening was carried out in pregnant women, and parasites were sought in the blood of newborns from seropositive mothers. {I}nfected infants were randomly assigned to two treatment groups. {R}ecovery was assessed by parasite seeking at 1 month and 2 months as well as serological tests at 9 months. {A}ssessment of treatment adherence was based on weekly home visits and use of electronic monitors. {R}esults: {B}enznidazole was given to 63 newborns in group {A} (5 mg/kg in two daily doses for 60 days) and 61 newborns in group {B} (7.5 mg/kg in a single daily dose for 30 days). {T}here was no difference in compliance between the two groups. {T}he study confirmed the efficacy and good tolerance of both benznidazole regimens in the treatment of congenital {C}hagas disease. {C}onclusions: {T}he short treatment should be preferred as it allows reducing the dose of benznidazole as well as the cost of treatment.},
  keywords = {{C}hagas disease ; {T}rypanosoma cruzi ; {C}linical trial ; {C}ompliance ; {B}enznidazole ; {B}olivia ; {BOLIVIE}},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {107},
  numero = {1},
  pages = {1--7},
  ISSN = {0035-9203},
  year = {2013},
  DOI = {10.1093/trstmh/trs004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060700},
}