@article{fdi:010060691,
  title = {{I}nduction of {CD}8(+) regulatory {T} cells protects macaques against {SIV} challenge},
  author = {{L}u, {W}ei and {C}hen, {S}. and {L}ai, {C}. {H}. and {G}uo, {W}. {Z}. and {F}u, {L}. {C}. and {A}ndrieu, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}fforts to develop a vaccine against {HIV} have so far met with limited success. {G}iven that {CD}4(+) {T} cell activation drives the initial burst of viral replication, we explored in macaques whether an oral vaccine comprised of {L}actobacillus plantarum, a commensal bacterium that favors immune tolerance, and inactivated simian immunodeficiency virus mac239 ({SIV}mac239) would induce {CD}4(+) {T} cell unresponsiveness/tolerance toward {SIV} antigens and thereby prevent the establishment of {SIV} infection. {T}he tolerogenic vaccine induced {MHC}-{I}b/{E}-restricted {CD}8(+) regulatory {T} cells ({T}regs) that suppressed {SIV}-harboring {CD}4(+) {T} cell activation and ex vivo {SIV} replication in 15 of 16 animals without inducing {SIV}-specific antibodies or cytotoxic {T} lymphocytes. {O}f 16 macaques that were intrarectally challenged with {SIV}mac239 or heterologous strain {SIVB}670, 15 were sterilely protected. {I}n four macaques that were rechallenged intravenously, plasma {SIV} levels peaked slightly and then dropped to undetectable levels, although the animals subsequently harbored intracellular {SIV} {DNA}. {I}nfusion of {CD}8 antibodies confirmed the role of {CD}8(+) {T}regs in preventing/suppressing {SIV} in vivo. {T}hese findings suggest a new avenue of research toward developing an {HIV}-1 vaccine.},
  keywords = {},
  booktitle = {},
  journal = {{C}ell {R}eports},
  volume = {2},
  numero = {6},
  pages = {1736--1746},
  ISSN = {2211-1247},
  year = {2012},
  DOI = {10.1016/j.celrep.2012.11.016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060691},
}