Cotillard A. auteur aut IRD Kennedy S. P. auteur aut IRD Kong L. C. auteur aut IRD Prifti E. auteur aut IRD Pons N. auteur aut IRD Le Chatelier E. auteur aut IRD Almeida M. auteur aut IRD Quinquis B. auteur aut IRD Levenez F. auteur aut IRD Galleron N. auteur aut IRD Gougis S. auteur aut IRD Rizkalla S. auteur aut IRD Batto J. M. auteur aut IRD Renault P. auteur aut IRD Dore J. auteur aut IRD Zucker Jean-Daniel auteur aut IRD Clement K. auteur aut IRD Ehrlich S. D. auteur aut IRD text journalArticle eng text/pdf born digital access Complex gene-environment interactions are considered important in the development of obesity(1). The composition of the gut microbiota can determine the efficacy of energy harvest from food(2-4) and changes in dietary composition have been associated with changes in the composition of gut microbial populations(5,6). The capacity to explore microbiota composition was markedly improved by the development of metagenomic approaches(7,8), which have already allowed production of the first human gut microbial gene catalogue(9) and stratifying individuals by their gut genomic profile into different enterotypes(10), but the analyses were carried out mainly in nonintervention settings. To investigate the temporal relationships between food intake, gut microbiota and metabolic and inflammatory phenotypes, we conducted diet-induced weight-loss and weight-stabilization interventions in a study sample of 38 obese and 11 overweight individuals. Here we report that individuals with reduced microbial gene richness (40%) present more pronounced dys-metabolism and low-grade inflammation, as observed concomitantly in the accompanying paper(11). Dietary intervention improves low gene richness and clinical phenotypes, but seems to be less efficient for inflammation variables in individuals with lower gene richness. Low gene richness may therefore have predictive potential for the efficacy of intervention. specialized 054 084 020 500 7464 585-588 + 2 2013 0028-0836 https://www.documentation.ird.fr/hor/fdi:010060599 10.1038/nature12480 0028-0836 [F B010060599] https://www.documentation.ird.fr/hor/fdi:010060599 https://www.documentation.ird.fr/intranet/publi/2013/09/010060599.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2013-10-02 2017-08-23 fdi:010060599 fre