@article{fdi:010060594,
  title = {{R}ichness of human gut microbiome correlates with metabolic markers},
  author = {{L}e {C}hatelier, {E}. and {N}ielsen, {T}. and {Q}in, {J}. {J}. and {P}rifti, {E}. and {H}ildebrand, {F}. and {F}alony, {G}. and {A}lmeida, {M}. and {A}rumugam, {M}. and {B}atto, {J}. {M}. and {K}ennedy, {S}. and {L}eonard, {P}. and {L}i, {J}. {H}. and {B}urgdorf, {K}. and {G}rarup, {N}. and {J}orgensen, {T}. and {B}randslund, {I}. and {N}ielsen, {H}. {B}. and {J}uncker, {A}. {S}. and {B}ertalan, {M}. and {L}evenez, {F}. and {P}ons, {N}. and {R}asmussen, {S}. and {S}unagawa, {S}. and {T}ap, {J}. and {T}ims, {S}. and {Z}oetendal, {E}. {G}. and {B}runak, {S}. and {C}lement, {K}. and {D}ore, {J}. and {K}leerebezem, {M}. and {K}ristiansen, {K}. and {R}enault, {P}. and {S}icheritz-{P}onten, {T}. and de {V}os, {W}. {M}. and {Z}ucker, {J}ean-{D}aniel and {R}aes, {J}. and {H}ansen, {T}. and {B}ork, {P}. and {W}ang, {J}. and {E}hrlich, {S}. {D}. and {P}edersen, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e are facing a global metabolic health crisis provoked by an obesity epidemic. {H}ere we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese {D}anish individuals. {W}e find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. {T}hey contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. {T}he obese individuals among the lower bacterial richness group also gain more weight over time. {O}nly a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. {O}ur classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature},
  volume = {500},
  numero = {7464},
  pages = {541--546 + 2},
  ISSN = {0028-0836},
  year = {2013},
  DOI = {10.1038/nature12506},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060594},
}