@article{fdi:010060531,
  title = {{I}mportance of adequate local spatiotemporal transmission measures in {M}alaria cohort studies : application to the relation between placental {M}alaria and first {M}alaria infection in infants},
  author = {{L}e {P}ort, {A}. and {C}ottrell, {G}illes and {C}handre, {F}abrice and {C}ot, {M}ichel and {M}assougbodji, {A}. and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ccording to several studies, infants whose mothers had a malaria-infected placenta ({MIP}) at delivery are at increased risk of a first malaria infection. {I}mmune tolerance caused by intrauterine contact with the parasite could explain this phenomenon, but it is also known that infants who are highly exposed to {A}nopheles mosquitoes infected with {P}lasmodium are at greater risk of contracting malaria. {C}onsequently, local malaria transmission must be taken into account to demonstrate the immune tolerance hypothesis. {F}rom data collected between 2007 and 2010 on 545 infants followed from birth to age 18 months in southern {B}enin, we compared estimates of the effect of {MIP} on time to first malaria infection obtained through different {C}ox models. {I}n these models, {MIP} was adjusted for either 1) "village-like" time-independent exposure variables or 2) spatiotemporal exposure prediction derived from local climatic, environmental, and behavioral factors. {O}nly the use of exposure prediction improved the model's goodness of fit ({B}ayesian {I}nformation {C}riterion) and led to clear conclusions regarding the effect of placental infection, whereas the models using the village-like variables were less successful than the univariate model. {T}his demonstrated clearly the benefit of adequately taking transmission into account in cohort studies of malaria.},
  keywords = {cohort studies ; infant ; malaria ; malaria transmission ; placenta},
  booktitle = {},
  journal = {{A}merican {J}ournal of {E}pidemiology},
  volume = {178},
  numero = {1},
  pages = {136--143},
  ISSN = {0002-9262},
  year = {2013},
  DOI = {10.1093/aje/kws452},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060531},
}