@article{fdi:010060508,
  title = {{A}n atypical age-specific pattern of hepatocellular carcinoma in {P}eru : a threat for {A}ndean populations},
  author = {{B}ertani, {S}t{\'e}phane and {P}ineau, {P}. and {L}oli, {S}. and {M}oura, {J}ulien and {Z}imic, {M}. and {D}eharo, {E}ric and {R}uiz, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n {S}outh {A}merica, the highest incidence of primary liver cancer is observed in {P}eru. {H}owever, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. {T}hus, there is a lack of tangible information from {P}eru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. {T}he present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country. {M}ethods: {A} retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the {P}eruvian national institute for cancer. {T}he medical records including liver function, serologic status, and tumor pathology and stage were monitored. {S}tatistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin. {R}esults: {S}urprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. {W}hile an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. {I}n addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics. {C}onclusions: {T}he analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the {P}eruvian patient population. {T}his otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a {P}eru-endemic risk factor driving hepatocarcinogenesis in the local population.},
  keywords = {{PEROU} ; {ANDES}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {6},
  pages = {e67756},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0067756},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060508},
}