@article{fdi:010060495,
  title = {{HLA}-{G} 3 ' {UTR}-2 haplotype is associated with {H}uman {A}frican trypanosomiasis susceptibility},
  author = {{C}ourtin, {D}avid and {M}ilet, {J}acqueline and {S}abbagh, {A}. and {M}assaro, {J}. {D}. and {C}astelli, {E}. {C}. and {J}amonneau, {V}incent and {B}ucheton, {B}runo and {S}ese, {C}. and {F}avier, {B}. and {R}ouas-{F}reiss, {N}. and {M}oreau, {P}. and {D}onadi, {E}. {A}. and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{T}rypanosoma brucei gambiense ({T}bg) is responsible for the chronic form of {H}uman {A}frican trypanosomiasis ({HAT}), classically lasting for years. {C}linical evolution of {HAT} cases seems to be complex and reports on asymptomatic carriers and spontaneous cure have been published recently, strengthening the likely existence of the phenomenon of human trypanotolerance. {H}ost's genetic factors could be involved in both the control of infection levels and the mortality rates, as clearly shown in experimental models, but also in human. {A}lthough genes directly involved in immune response are important candidates, genes implicated in the regulation of immunity, such as {HLA}-{G}, could also play a critical role. {A} candidate gene association study was previously conducted in the {D}emocratic {R}epublic of {C}ongo using a family-based sample including 106 families (n = 353). {A}ll individuals, from the {Y}ansi ethnic group, were born in the area and had been exposed to the risk of infection since birth. {W}e sequenced the {HLA}-{G} 3' untranslated region ({UTR}) and performed a family based association analysis of the 14 polymorphisms identified (14-bp insertion/deletion plus 13 {SNP}s). {T}hree polymorphisms, 14-bp insertion/deletion and {SNP}s located at the +3003 and +3196 positions were associated to {HAT} ({FBAT} p = 0.008, p = 0.015 and p = 0.022, respectively). {HLA}-{G} 3' {UTR} haplotypes were significantly associated with {HAT} ({HBAT}, global p = 0.0026). {UTR}-2 haplotype (including 14-pb insertion and {G} allele at position +3196) was over-transmitted to the affected offspring ({HBAT} p = 0.003) at the expense of {UTR}-4 haplotype, which was under-transmitted ({HBAT} p = 0.013). {T}hese results are the first to report an association between polymorphisms in {HLA}-{G} and variable risks to develop {HAT} and suggest the involvement of the {HLA}-{G} molecule on {HAT} susceptibility.},
  keywords = {{H}uman {A}frican trypanosomiasis ; {S}leeping sickness ; {HLA}-{G} ; {G}enetic susceptibility ; {UTR} ; {H}aplotype ; {CONGO} ({RDC})},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {17},
  numero = {},
  pages = {1--7},
  ISSN = {1567-1348},
  year = {2013},
  DOI = {10.1016/j.meegid.2013.03.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060495},
}