@article{fdi:010060447,
  title = {{A}ssociation of {HLA}-{G} 3 ' {UTR} polymorphisms with response to malaria infection : a first insight},
  author = {{G}arcia, {A}ndr{\'e} and {M}ilet, {J}acqueline and {C}ourtin, {D}avid and {S}abbagh, {A}. and {M}assaro, {J}. {D}. and {C}astelli, {E}. {C}. and {M}igot {N}abias, {F}lorence and {F}avier, {B}. and {R}ouas-{F}reiss, {N}. and {D}onadi, {E}. {A}. and {M}oreau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria represents one of the most important causes of mortality and morbidity in {A}frica. {V}ariability in clinical presentation is partly due to host genetic polymorphisms. {A}mong them, human leukocyte antigen ({HLA}) class {I} and class {II} alleles may be responsible for malaria susceptibility; however less is known about the possible role of non classical {HLA} molecules. {A}mong them, {HLA}-{G} is a tolerogenic molecule with immunomodulatory properties, which differs from classical {HLA} class {I} molecules by its lower genetic diversity, tissue expression and function. {A}lthough primarily associated with maternal-fetal tolerance, {HLA}-{G} is now known to be involved in a wide range of physiopathological conditions, such as tumor, autoimmunity, transplantation, inflammation and viral infection by suppressing the function of various immune cells. {I}n this work, we present the first evidence of an association between {HLA}-{G} 3'{UTR} polymorphisms and malaria infection. {M}ore precisely, we showed that {HLA}-{G} polymorphisms are associated with asymptomatic infection through two parasitological phenotypes, the intensity of {P}lasmodium falciparum infection and the mean level of parasite density. {T}he allele + 3187{G} and its haplotype ({UTR}-1, 14 bp-{D}el/3001{C}/3003{T}/3010{G}/3035{C}/3052{C}/3142{C}/3187{G}/3196{C}) was associated with lower level of infection under a dominant model, and the haplotype {UTR}-3 ({D}el/3001{C}/3003{T}/3010{C}/3035{C}/3152{C}/3142{G}/3187{A}/3196{C}) was associated with high levels of infection under a recessive model. {I}n conclusion, although further investigations are on the way to better address the possible involvement of the {HLA}-{G} molecule in the control of {P}. falciparum infection, this work presents the first evidence of an association between {HLA}-{G} polymorphisms and malaria infection. {F}urther investigations are on the way to take into account the particularities of {A}frican populations.},
  keywords = {{M}alaria ; {HLA}-{G} 3 ' {UTR} ; {F}amily-based association ; {H}aplotype analysis ; {I}mmune development ; {SENAGAL} ; {NIAKHAR}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {16},
  numero = {},
  pages = {263--269},
  ISSN = {1567-1348},
  year = {2013},
  DOI = {10.1016/j.meegid.2013.02.021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060447},
}