@article{fdi:010060439,
  title = {{H}igh rates of parasite recrudescence following intermittent preventive treatment with sulphadoxine-pyrimethamine during pregnancy in {B}enin},
  author = {{M}oussiliou, {A}. and {D}e {T}ove, {Y}. {S}. {S}. and {D}oritchamou, {J}. and {L}uty, {A}drian and {M}assougbodji, {A}. and {A}lifrangis, {M}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {D}espite widespread parasite resistance to sulphadoxine-pyrimethamine ({SP}) its use for intermittent preventative treatment during pregnancy remains the policy in {B}enin and throughout most of sub-{S}aharan {A}frica. {M}ethods: {I}n a prospective study, 982 pregnant women were recruited in {B}enin and followed until delivery. {T}he prevalence of point mutations in the pfdhfr and pfdhps genes associated with {P}lasmodium falciparum resistance to {SP} during consecutive antenatal visits was determined. {P}arasites clearance among women infected at {SP} intake was assessed by microscopy and {PCR}. {A}ssociation between the persistence of parasites and malaria consequences, were investigated. {R}ecurrent parasites were genotyped to identify recrudescences from re-infections. {R}esults: {T}he prevalence of pfdhfr/pfdhps quadruple mutants (triple pfdhfr + single pfdhps) was consistently above 80% while quintuple and sextuple mutants remained low. {I}mportantly the higly mutated parasites apparently never included the two key mutations, pfdhfr 164 {L} or pfdhps 540{E}. {B}ased on {PCR} results, {SP} failed to clear existing parasitaemia in half (48%) of the women who were infected at {IPT}p schedule. {T}he frequency of recrudescence reached 76% after the second dose. {W}omen with persistent parasitaemia had an increased prevalence of anaemia ({P} = 0.03). {C}onclusion: {T}he data presented here, highlight the inability of {SP} to ensure optimal antiplasmodial protection in late pregnancy, and invite urgent consideration of an alternative drug or strategy.},
  keywords = {{P}lasmodium falciparum ; {P}regnancy ; {IPT}p ; {S}ulphadoxine-pyrimethamine ; {M}utations ; pfdhfr ; pfdhps ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {12},
  numero = {},
  pages = {195},
  ISSN = {1475-2875},
  year = {2013},
  DOI = {10.1186/1475-2875-12-195},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060439},
}