Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Journal of Reproductive Immunology 21-28 Pregnancy Peripheral blood mononuclear cells African women Longitudinal cohort study Lymphocytes Antigen-presenting cells AFRIQUE SUBSAHARIENNE 2013 fdi:010060425 ENG Journal of Reproductive Immunology 0165-0378 ISI:000320220500003 1-2 10.1016/j.jri.2013.03.002 https://www.documentation.ird.fr/hor/fdi:010060425 https://www.documentation.ird.fr/intranet/publi/2013/07/010060425.pdf 98 Horizon (IRD) Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4(+) T cells declined significantly, contrasting with a non-significant increase in CD8(+) T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others. 050 UR216 Bénin