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    <titleInfo>
      <title>How clonal are Trypanosoma and Leishmania ?</title>
    </titleInfo>
    <name type="personnal">
      <namePart type="family">Tibayrenc</namePart>
      <namePart type="given">Michel</namePart>
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        <roleTerm type="text">auteur</roleTerm>
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      </role>
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    </name>
    <name type="personnal">
      <namePart type="family">Ayala</namePart>
      <namePart type="given">F. J.</namePart>
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    <abstract>The clonal theory of parasitic protozoa has been recently challenged by researchers stating that recombination in Kinetoplastida is much more frequent than previously believed, or that selfing and homogamy should be distinguished from 'strict' clonality. These researchers and many others show that the concept of clonality proposed by us is not correctly understood. A recapitulation of the clonal theory will thus be addressed herein. Comparisons with various other pathogens evidence general features among them and enhance our understanding of Trypanosome and Leishmania population genetics. The relevance is considerable not only for our knowledge of the basic biology of these organisms but also for applied research: molecular epidemiology (strain-typing), clinical research, vaccine and drug design, and experimental evolution.</abstract>
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    <subject>
      <topic>Kinetoplastida</topic>
      <topic>clonality</topic>
      <topic>population genetics</topic>
      <topic>molecular epidemiology</topic>
      <topic>linkage disequilibrium</topic>
      <topic>preponderant clonal evolution</topic>
      <topic>selfing</topic>
      <topic>homogamy</topic>
    </subject>
    <classification authority="local">052</classification>
    <relatedItem type="host">
      <titleInfo>
        <title>Trends in Parasitology</title>
      </titleInfo>
      <part>
        <detail type="volume">
          <number>29</number>
        </detail>
        <detail type="volume">
          <number>6</number>
        </detail>
        <extent unit="pages">
          <list> 264-269</list>
        </extent>
      </part>
      <originInfo>
        <dateIssued>2013</dateIssued>
      </originInfo>
      <identifier type="issn">1471-4922</identifier>
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    <identifier type="uri">https://www.documentation.ird.fr/hor/fdi:010060422</identifier>
    <identifier type="doi">10.1016/j.pt.2013.03.007</identifier>
    <identifier type="issn">1471-4922</identifier>
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      <recordCreationDate encoding="w3cdtf">2013-07-29</recordCreationDate>
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