Khamduang W. auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Gaudy-Graffin C. auteur aut IRD Jourdain Gonzague auteur aut IRD Suwankornsakul W. auteur aut IRD Jarupanich T. auteur aut IRD Chalermpolprapa V. auteur aut IRD Nanta S. auteur aut IRD Puarattana-aroonkorn N. auteur aut IRD Tonmat S. auteur aut IRD Lallemant Marc auteur aut IRD Goudeau A. auteur aut IRD Sirirungsi W. auteur aut IRD text journalArticle eng text/pdf born digital access Background. Prevalence and risk factors for isolated antibody to hepatitis B core antigen (anti-HBc) and occult hepatitis B virus (HBV) infection are not well known in human immunodeficiency virus type 1 (HIV-1)-infected pregnant women. It is unclear if women with occult infections are at risk of transmitting HBV to their infants. Methods. HIV-1-infected and HBV surface antigen (HBsAg)-negative pregnant women were tested for anti-body to HBsAg (anti-HBs) and anti-HBc using enzyme immunoassay. Women with isolated anti-HBc were assessed for occult HBV infection, defined as HBV DNA levels >15 IU/mL, using the Abbott RealTime HBV DNA assay. Infants born to women with isolated anti-HBc and detectable HBV DNA were tested at 4 months of age for HBV DNA. Logistic regression analysis was used to identify factors associated with isolated anti-HBc and occult HBV infection. Results. Among 1812 HIV-infected pregnant women, 1682 were HBsAg negative. Fourteen percent (95% confidence interval [CI], 12%-15%) of HBsAg-negative women had an isolated anti-HBc that was independently associated with low CD4 count, age >35 years, birth in northern Thailand, and positive anti-hepatitis C virus serology. Occult HBV infection was identified in 24% (95% CI, 18%-30%) of women with isolated anti-HBc, representing 2.6% (95% CI, 1.9%-3.5%) of HIV-1-infected pregnant women, and was inversely associated with HIV RNA levels. None of the women with isolated anti-HBc and occult HBV infection transmitted HBV to their infants. Conclusions. HIV-1-infected pregnant women with isolated anti-HBc and occult HBV infection have very low HBV DNA levels and are thus at very low risk to transmit HBV to their infants. specialized HIV-1-infected pregnant women isolated anti-HBc occult HBV infection perinatal transmission THAILANDE 052 050 56 12 1704-1712 2013 1058-4838 https://www.documentation.ird.fr/hor/fdi:010060135 10.1093/cid/cit166 1058-4838 [F B010060135] https://www.documentation.ird.fr/hor/fdi:010060135 https://www.documentation.ird.fr/intranet/publi/depot/2013-10-28/010060135.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2013-07-29 2017-08-23 fdi:010060135 fre