Ndille E.E. auteur aut IRD Doucouré S. auteur aut IRD Damien G. auteur aut IRD Mouchet François auteur aut IRD Dramé Papa Maktar auteur aut IRD Cornélie Sylvie auteur aut IRD Noukpo H. auteur aut IRD Yamadjako S. auteur aut IRD Djenontin A. auteur aut IRD Moiroux Nicolas auteur aut IRD Missé Dorothée auteur aut IRD Akogbeto M. auteur aut IRD Corbel Vincent auteur aut IRD Henry M.C. auteur aut IRD Chandre Fabrice auteur aut IRD Baldet T. auteur aut IRD Remoué Franck auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background: Much effort is being devoted for developing new indicators to evaluate the human exposure to Aedes mosquito bites and the risk of arbovirus transmission. Human antibody (Ab) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact. Methodology/Principal findings: To develop a specific biomarker of human exposure to Aedes aegypti bites, we measured IgG Ab response to Ae. aegypti Nterm-34 kDa salivary peptide in exposed children in 7 villages of Southern Benin (West Africa). Results showed that specific IgG response presented high inter-individual heterogeneity between villages. IgG response was associated with rainfall and IgG level increased from dry (low exposure) to rainy (high exposure) seasons. These findings indicate that IgG Ab to Nterm-34 kDa salivary peptide may represent a reliable biomarker to detect variation in human exposure to Ae. aegypti bites. Conclusion/Significance: This preliminary study highlights the potential use of Ab response to this salivary peptide for evaluating human exposure to Ae. aegypti. This biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions. specialized BENIN 052 050 6 11 e1905 2012 1935-2735 https://www.documentation.ird.fr/hor/fdi:010058996 10.1371/journal.pntd.0001905 1935-2735 [F B010058996] https://www.documentation.ird.fr/hor/fdi:010058996 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010058996.pdf IRD - Base Horizon / Pleins textes 2013-04-02 2021-01-16 fdi:010058996 fre